Qhaus nplooj Alkaloid Extract lus Sedative – Hypnotic thiab Anxiolytic los ntawm GABAA Receptor

Qhaus nplooj muaj siv feeb ntau ua rau cov zaub mov thiab herbal tshuaj nyob hauv cov teb chaws Asia. Qhib-teb, sodium pentobarbital hob tsaug zog

thiab lub thawv teeb/maub kev tshuaj ntsuam tau siv los soj ntsuam sedative – hypnotic thiab anxiolytic los ntawm tus nqi alkaloids (TA) muab rho tawm los ntawm cov tshuaj ntsuab,

thiab cov qib neurotransmitter hauv lub paj hlwb tau txiav txim tau los ultrafast kua chromatography – tandem huab hwm coj spectrometry. Hauv

picrotoxin, flumazenil, thiab bicuculline rau txoj kev ua hypnotic ntawm TA, thiab raws li cawv ntawm TA rau Cl influx nyob cerebellar granule

hlwb, tau los tshawb xyuas. TA tsom ib sedative – hypnotic nyhuv uas ua rau hlwb theem ntawm γ-aminobutyric acid (GABA), thiab cov

hypnotic nyhuv yuav tsum sim los ntawm picrotoxin thiab bicuculline, tab sis kuj yuav tsis raug antagonized los ntawm flumazenil. Ntxiv thiab, TA yuav ua

Cl influx hauv hlwb cerebellar granule. TA ntawm 20 mg/kg vim raug yuam los zoo li anxiolytic thiab si tau qhov ntau ntawm

serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), thiab dopamine (DA). Cov ntaub ntawv no pom hais tias nws tias TA exerts sedative-hypnotic

thiab anxiolytic los ntawm binding rau lub GABAib receptor thiab activating lawv monoaminergic.