Tib neeg kev ntshiab Albumin Vocabulary ntawm lub ntuj Herbal Extract ntawm Stryphnodendron Polyphyllum STD NMR, Hyphenations thiab Docking Simulation Studies

Lub dhau ob xyoo lawm, tshiab thiab cov tswv yim siab ntau heev uas pab ceev ceev mus kuaj thiab tshawb kev tshiab ligands rau ib macromolecule ib

muaj dua ib tug sau ib yam tseem ceeb. Ntawm seem yus pom no, cov hauj lwm zoo STD NMR, Tr-NOESY thiab STD-TOCSY muaj tau ntaub ntsuam xyuas qhov kev ruaj

tej zaum lub ntuj extract ntawm Stryphnodendron polyphyllum, siv los ua ib tug herbal tshuaj hauv Brazil, ntawm cov neeg albumin. Ntxiv thiab, 1D-DOSY

thwmsim muaj kuj tau nyob rau lub discriminations ntawm molecular ceeb thawj txawv tebchaw tam sim no nyob rau hauv no extract. Tom qab cov STD, Tr-NOESY,

thiab TOCSY soj lus, lub kaw lus ntxiv comprising LC-SPE-NMR yog ntaub saib lub teb yam ntxwv tibsi ntawm 2D spectra. Tus

tag nrho ntawm NMR spectroscopy thiab sib cais kev pab myricetin-3-O- rhamnopyranoside (1), quercetin-3-O- glucopyranoside (2),

quercetin-3-O- xylopyranoside (3), thiab quercetin-3-O- rhamnopyranoside (4) tias tus active site blockers. Ntxiv thiab, epitope tau thiab ntxiv Tr-NOESY

Cross tej peaks pom tias muaj cov cov conformations ntawm cov ligands hauv lub ligand-HSA complex ntawm lub ntug protons pluav. STD mob(nurses),

kev tshawb fawb sib txeeb nrog cov ligand – HSA complex tau pom hais tias nws yog varying cov concentration ntawm molecule neeg soj xyuas uas xyua xim binds nrog Sudlow cov chaw II.

Thaum kawg, docking simulations targeting ob lub chaw Sudlow (kuv thiab II) los tau, uas interestingly ntsi xws li qhov txheeb xyuas tau STD sib txeeb thiab tsom uas

cov tebchaw (1 – 4) no mas nws muaj ntsis ntawm kev kawm ntawv-1 inhibition ruaj. Yog li ntawd, peb hais tias lawv liag cov hom kev kawm nyob rau hauv txoj kev tshawb no yuav

yuav tau nrog ib tug yooj yooj yim thiab ceev analytical uas xyuas tej yam ntuj tso cia kom zoo zog ua rau tej hom phiaj.